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FNDC 5 could be regulated by leptin in adipose tissue
Author(s) -
GutierrezRepiso Carolina,
GarciaSerrano Sara,
RodriguezPacheco Francisca,
GarciaEscobar Eva,
HaroMora Juan J.,
GarciaArnes Juan,
Valdes Sergio,
Gonzalo Montserrat,
Soriguer Federico,
MorenoRuiz Francisco J.,
RodriguezCañete Alberto,
MartinezFerriz Abelardo,
Santoyo Julio S.,
PerezValero Vidal,
GarciaFuentes Eduardo
Publication year - 2014
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12324
Subject(s) - leptin , adipose tissue , medicine , endocrinology , obesity , morbidly obese , morbid obesity , weight loss
Irisin activates the thermogenic function in adipose tissues. However, little is known on the association between human irisin and different cardiometabolic risk factors. We analyse the influence of morbid obesity on irisin levels and its relation with leptin and different cardiovascular risk factors. Material and methods We measured the serum irisin level and the fibronectin type III domain containing 5 ( FNDC 5) expression in adipose tissue from 33 morbidly obese subjects and 12 nonobese subjects. We also studied the effect of leptin on FNDC 5 expression. Results Serum irisin was higher in the nonobese subjects than in morbidly obese subjects, both before ( P = 0·043) and after bariatric surgery ( P = 0·042). The variable that best explained the serum irisin levels in a multiple linear regression model was the waist‐to‐hip ratio ( WHR ) (R 2 = 0·201) (Beta = −0·357, P = 0·046). Those morbidly obese subjects with android‐type obesity had lower serum irisin levels than those with gynecoid‐type obesity, both before ( P = 0·027) and after bariatric surgery ( P = 0·006). Only the percentage change in WHR was associated with serum irisin levels after bariatric surgery ( r = −0·529, P = 0·005). FNDC 5 expression levels in subcutaneous adipose tissue ( SAT ) were higher in the nonobese than in the morbidly obese subjects ( P = 0·042). In SAT explants from nonobese subjects, leptin (20 and 150 ng/mL) produced a decrease in FNDC 5 expression ( P = 0·009 and P = 0·037, respectively). Conclusions We showed decreased serum irisin levels in morbidly obese subjects, related mainly to WHR . FNDC 5 expression could be regulated by leptin.