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Delayed vasodilation is associated with cardiovascular risk
Author(s) -
Irace Concetta,
Padilla Jaume,
Carallo Claudio,
Scavelli Faustina,
Gnasso Agostino
Publication year - 2014
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12268
Subject(s) - medicine , vasodilation , cardiology , brachial artery , blood pressure
Background Flow‐mediated dilation ( FMD ) of the brachial artery is widely used to assess cardiovascular risk. In recent years, much attention has been paid to the kinetics of vasodilation in an attempt to better characterize the endothelial function. Here, we investigated whether FMD magnitude and/or latency are most related to individual cardiovascular risk. Materials and methods Four hundred subjects were recruited. Individual risk prediction was estimated by F ramingham cardiovascular risk score and CUORE project calculator. Subjects were divided into Early dilators (peak FMD at 50 s), L ate dilators (peak FMD over 50 s) and N o dilators. Results Cardiovascular risk was highest in No dilators and significantly higher in L ate than E arly dilators despite comparable peak FMD . When divided according to peak FMD quintiles, E arly and L ate dilators showed decreased cardiovascular risk with increasing magnitude of vasodilation. However, subjects in the first three quintiles of L ate dilators had a markedly higher risk score despite a peak vasodilation similar to that of E arly dilators. Conclusion These results suggest that the magnitude of the FMD and its latency are both important for identifying patients at risk of cardiovascular disease. Subjects with a delayed though significant vasodilation associated with a blunted early response exhibit the highest cardiovascular risk.