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Monthly haemostatic factor variability in women and men
Author(s) -
Hill Alison M.,
Stewart Paul W.,
Fung Mark K.,
KrisEtherton Penny M.,
Ginsberg Henry N.,
Tracy Russell P.,
Pearson Thomas A.,
Lefevre Michael,
Reed Roberta G.,
Elmer Patricia J.,
Holleran Stephen,
Ershow Abby G.
Publication year - 2014
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12235
Subject(s) - menstrual cycle , fibrinogen , medicine , menopause , postmenopausal women , endocrinology , plasminogen activator inhibitor 1 , plasminogen activator , physiology , hormone
Background Hormonal status influences haemostatic factors including fibrinogen, factor VII and plasminogen activator inhibitor ( PAI ‐1), and concentrations differ among men, premenopausal and postmenopausal women. This study examines how phases of the menstrual cycle influence variability of fibrinogen, factor VII and PAI ‐1. Design We studied 103 subjects (39 premenopausal women, 18 postmenopausal women and 46 men) during three, randomized, 8‐week energy‐ and nutrient‐controlled experimental diets in the Dietary Effects on Lipids and Thrombogenic Activity ( DELTA ) Study. Fasting blood samples were collected weekly during the last 4 weeks of each diet period, and haemostatic factors were quantified. Two linear mixed‐effects models were used for fibrinogen, factor VII and PAI ‐1: one to estimate and compare group‐specific components of variance, and the other to estimate additional fixed effects representing cyclical functions of day of menstrual cycle in premenopausal women. Results Systematic cyclical variation with day of menstrual cycle was observed for fibrinogen ( P < 0·0001), factor VII ( P = 0·0012) and PAI ‐1 ( P = 0·0024) in premenopausal women. However, the amplitude of cycling was small relative to the total magnitude of intra‐individual variability. In addition, the intra‐individual variance and corresponding coefficient of variation observed in premenopausal women did not differ from postmenopausal women and men. Conclusions The variability in haemostatic factors in premenopausal women is no greater than for postmenopausal women or men. Consequently, premenopausal women can be included in studies investigating haemostatic factor responses without controlling for stage of menstrual cycle.