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Lipoproteins and H edgehog signalling – possible implications for the adrenal gland function
Author(s) -
Swierczynska Marta M.,
LamounierZepter Valéria,
Bornstein Stefan R.,
Eaton Suzanne
Publication year - 2013
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12145
Subject(s) - function (biology) , adrenal gland , signalling , endocrinology , chemistry , medicine , microbiology and biotechnology , biology
Abstract Background Metabolic syndrome is a common metabolic disorder that is associated with an increased risk of type 2 diabetes and cardiovascular diseases. Disturbances in adrenal steroid hormone production significantly contribute to the development of this disorder. Therefore, it is extremely important to fully understand the mechanisms governing adrenal gland function, both in physiological and pathological conditions. Results Recently, S onic hedgehog has emerged as an important regulator of adrenal development, with a possible role in adult gland homeostasis. Recent work of our group shows that lipoproteins are important regulators of H edgehog signaling; they act as carriers for the spread of Hedgehog proteins, but also contain lipid(s) that inhibit the pathway. Conclusions We propose that lipoproteins may affect S onic hedgehog signaling in the adult adrenal gland at multiple levels. Understanding the interplay between lipoprotein metabolism and adrenal H edgehog signaling may improve our understanding of how adrenal gland disorders contribute to the metabolic syndrome.