Premium
Non‐ HDL cholesterol vs. Apo B for risk of coronary heart disease in healthy individuals: the EPIC ‐Norfolk prospective population study
Author(s) -
Sondermeijer Brigitte M.,
Rana Jamal S.,
Arsenault Benoit J.,
Shah Prediman K.,
Kastelein John J.P.,
Wareham Nicholas J.,
Boekholdt S. Matthijs,
Khaw KayTee
Publication year - 2013
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12129
Subject(s) - hazard ratio , medicine , quartile , prospective cohort study , european prospective investigation into cancer and nutrition , confidence interval , apolipoprotein b , proportional hazards model , population , cholesterol , high density lipoprotein , endocrinology , environmental health
Background There is an ongoing debate about the performance of non–high‐density lipoprotein cholesterol (non‐ HDL ‐C) compared with apolipoprotein B (apo B) in the prediction of coronary heart disease ( CHD ) risk. Therefore, we compared the associations between non‐ HDL ‐C and apo B in regard to CHD among apparently healthy Western E uropean individuals. Design In the E uropean Prospective Investigation into Cancer and Nutrition ( EPIC )‐Norfolk prospective population study, 25 639 men and women aged 45–79 years were followed for 11·4 ± 2·8 years. Those with diabetes or prevalent CHD at baseline were excluded. A total of 2066 (12·1%) participants developed CHD during 195 692 person‐years follow‐up. Results The multivariable‐adjusted hazard ratio [ HR ] of future CHD per one standard deviation increase was 1·22 [95% confidence interval ( CI ): 1·17–1·27] for LDL ‐C, 1·26 (95% CI 1·20–1·31) for non‐ HDL ‐C and 1·19 (95% CI 1·14–1·24) for apo B, respectively. The multivariable‐adjusted HR of future CHD in the highest quartile LDL ‐C was 1·67 (95% CI : 1·47–1·91). For non‐ HDL ‐C and apo B, these respective HR s were 1·87 (95% CI : 1·62–2·15) and 1·56 (95% CI : 1·36–1·78). Kaplan–Meier survival analyses showed that there was incremental and comparable increase in risk of CHD with increasing quartiles of both non‐ HDL ‐C and apo B. Conclusions In this prospective study, non‐ HDL ‐C and apo B were comparable in their ability to predict risk of future CHD .