C‐reactive protein and incidence of type 2 diabetes in the Pizarra study

Aim To determine the association between serum levels of high‐sensitivity C ‐reactive protein (hs‐ CRP ) and the incidence of type 2 diabetes in a prospective cohort from southern S pain ( P izarra study). Materials and methods The study formed part of the P izarra cohort study, a prospective study started in 1995 with a follow‐up of 11 years. Anthropometric and metabolic variables were measured at baseline and at 6 years and 11 years of follow‐up . All subjects underwent an oral glucose tolerance test. Serum levels of TNF α and its receptors, hs‐ CRP , IL ‐6, leptin, adiponectin and FABP 4 were measured at 6 years of follow‐up. Results After adjusting for age, sex and obesity, subjects with levels of hs‐ CRP > 2.9 mg/L in the second study (2003–4) had a higher risk of developing type 2 diabetes by the third study (2008–9) ( OR  = 7.97; 95% CI  = 1.72–36.89; P  = 0.008), and subjects with adiponectin levels > 13.2 mg/L had a lower risk of developing type 2 diabetes ( OR  = 0.23, P  = 0.02). High values of hs‐ CRP and high values of adiponectin were associated positively ( OR  = 8.26; 95% CI  = 1.84–37.19; P  = 0.006) and negatively ( OR  = 0.17; 95% CI  = 0.04–0.69; P  = 0.01), respectively, with the risk of having H b A 1c ≥ 6.5% at 11 years of follow‐up. Conclusions Subjects with high serum hs‐ CRP levels and low serum adiponectin levels have a higher risk of developing type 2 diabetes within five years.