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One‐hour post‐load plasma glucose and IGF‐1 in hypertensive patients
Author(s) -
Perticone Francesco,
Sciacqua Angela,
Tassone Eliezer J.,
Miceli Sofia,
Maio Raffaele,
Addesi Desirée,
Falbo Tania,
Arturi Franco,
Sesti Giorgio
Publication year - 2012
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/eci.12005
Subject(s) - medicine , immunoradiometric assay , endocrinology , insulin resistance , impaired glucose tolerance , subclinical infection , type 2 diabetes , diabetes mellitus , plasma glucose , glucose tolerance test , insulin sensitivity , insulin , radioimmunoassay
Eur J Clin Invest 2012; 42 (12): 1325–1331 Abstract Background In normoglucose‐tolerant subjects (NGT), 1‐h post‐load plasma glucose value ≥155 mg/dL, during an oral glucose tolerance test (OGTT), is associated with an increased risk of type‐2 diabetes (T2D) and subclinical organ damage. Insulin‐like growth factor‐1 (IGF‐1) is involved in the pathogenesis of insulin resistance (IR) and T2D. Moreover, hypertensives have different degrees of IR and different levels of IGF‐1. Actually, there are no data supporting the association between post‐load glucose and IGF‐1; thus, the aim of the study was to investigate this relationship. Materials and methods We enrolled 1126 never‐treated hypertensive subjects who underwent an OGTT and clinical characterization. Insulin sensitivity was assessed by the Matsuda index. IGF‐1 was measured by a sensitive immunoradiometric assay. Results Among participants, 764 had NGT, 263 had impaired glucose tolerance (IGT) and 99 had T2D. According to the 1‐h post‐load plasma glucose cut‐off point of 155 mg/dL, we divided NGT subjects into NGT < 155 mg/dL and NGT ≥ 155 mg/dL. NGT ≥ 155 in comparison with NGT < 155 had significantly reduced insulin sensitivity and IGF‐1 levels. At multiple regression analysis, IGF‐1 was the major determinant of 1‐h post‐load glucose in NGT ≥ 155 subjects, IGT and diabetics, accounting for 20·9%, 17·7% and 15·5% of its variation in the respective models. Conclusions In hypertensive NGT ≥ 155 subjects, IGF‐1 results strongly associated with 1‐h post‐load glucose, similarly to that observed in IGT and diabetics. This finding has clinical relevance because both low IGF‐1 levels and 1‐h post‐load glucose in NGT subjects are associated with subclinical organ damage, an independent predictor of cardiovascular events.