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Semiquantitative assessment of the relative apical sparing pattern of longitudinal strain for cardiac amyloidosis identification
Author(s) -
Saito Makoto,
Imai Misaki,
Wake Daisuke,
Higaki Rieko,
Nakao Yasuhisa,
Sumimoto Takumi,
Yokomoto Yuki,
Ogimoto Akiyoshi,
Suzuki Moeko,
Kawakami Hideo,
Hiasa Go,
Okayama Hideki,
Inoue Katsuji,
Ikeda Shuntaro,
Yamaguchi Osamu
Publication year - 2020
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.14833
Subject(s) - medicine , basal (medicine) , quantitative assessment , concordance , reproducibility , cardiac amyloidosis , area under the curve , amyloidosis , cardiology , mathematics , risk analysis (engineering) , statistics , insulin
Backgrounds The relative apical sparing pattern (RASP) of left ventricular (LV) longitudinal strain (LS) is frequently associated with cardiac amyloidosis (CA). However, the visual assessment of RASP is inconsistent, and the quantitative assessment of RASP is time‐consuming. This study aimed to compare assessments of RASP for the identification of CA with conventional assessments and investigate their reproducibility and relevance on the assessments. Methods Forty patients with biopsy‐proven CA were compared with 80 hypertrophied patients matched for mean LV wall thickness. We compared the discriminative abilities of three assessments of RASP to identify CA (visual, quantitative, and semiquantitative). Nine patterns of semiquantitative RASP were investigated; finally, it was defined as “reduction of LS” (≥ −10%) in ≥5 (of 6) basal segments, relative to “preserved LS” (< −15%) in at least one apical segment. Results The concordance between the two observers for visual RASP was modest ( κ = 0.65). On the other hand, the consistency for semiquantitative RASP was perfect ( κ = 1.00). The discriminative ability of semiquantitative RASP (area under the curve [AUC] = 0.74) was significantly better than that of visual RASP (AUC = 0.65) and equivalent to that of binary quantitative RASP. Conclusion Semiquantitative RASP assessment is reproducible and accurately discriminates CA. This simple assessment may help readily refine the risk stratification of patients with diffuse LV hypertrophy.