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Who is young at heart and when? Diastolic Doppler data from the mind your heart study
Author(s) -
Abuzaid Ahmed,
Cohen Beth E.,
Pursnani Seema,
Lahsaeizadeh Seba,
Ristow Bryan,
Shaw Richard E.,
Rosenblatt Andrew,
Fang Qizhi,
Schiller Nelson B.
Publication year - 2019
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.14468
Subject(s) - medicine , diastole , odds ratio , demography , logistic regression , cardiology , population , cohort , dominance (genetics) , blood pressure , biochemistry , chemistry , environmental health , sociology , gene
To further define the age‐related distribution of diastolic function as defined by E/A ratio, in healthy male adults. The age‐sensitive ratio of mitral inflow E‐wave to A‐wave (E/A) velocity is often considered in the evaluation of diastolic function. To appropriately direct a comprehensive evaluation of diastolic function, we sought to improve the characterization of the influence of age on E/A ratio. We analyzed echocardiographic data from the Mind Your heart Study, a cohort of outpatients recruited from two San Francisco Veterans centers to examine the effect of mental health on cardiovascular outcomes. Individuals with a history of heart disease or hypertension were excluded, leaving 313 veterans for analysis. We examined E/A by 5‐year increments and performed linear and logistic regression analysis to predict trends in E/A and E dominance. Within the age ranges of population (54.9 ± 11.5), there is a steady gradual decline in absolute E/A ratio (beta coefficient/year‐ 0.018, P < .001) and the odds of E dominance similarly declines with age (odds ratio/year = 0.89, P < .001). Despite this decline, 90% of individuals below the age of 50 years maintain E dominance. Beyond age 50, 55% maintain E dominance, and beyond age 70, only 28% have E dominance. In this adequately healthy population, age‐related progression of delayed relaxation appears to be a state of normality rather than diastolic dysfunction. Careful attention to specific cutoff points in age and E/A ratio could avoid misinterpretation or inappropriate management.