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Pulmonary transit time from contrast echocardiography and cardiac magnetic resonance imaging: Comparison between modalities and the impact of region of interest characteristics
Author(s) -
Monahan Ken,
Coffin Samuel,
Lawson Mark,
Saliba Linda,
Rutherford Ray,
Brittain Evan
Publication year - 2019
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.14209
Subject(s) - medicine , cardiac magnetic resonance imaging , magnetic resonance imaging , cardiology , contrast (vision) , cardiac magnetic resonance , correlation , region of interest , nuclear medicine , radiology , mathematics , geometry , artificial intelligence , computer science
The degree of correlation of pulmonary transit time ( PTT ) between contrast echocardiography and cardiac magnetic resonance imaging ( MRI ) across the spectrum of cardiac disease has not been quantified. In addition, the degree to which PTT estimates are affected by variation in location and size of regions of interest ( ROI ) is unknown. Methods Pulmonary transit time was obtained using an inflection point technique from individuals that underwent contrast echocardiography and cardiac MRI . Right ventricular, left atrial, and left ventricular ROI s were evaluated, and two sizes for each ROI were used. The Spearman correlation coefficient and Bland–Altman analysis were used for comparisons between modalities. Bland–Altman plots were also used to measure the impact of ROI size and location on transit times. Results Fourteen participants (age: 27–64 years; LV ejection fraction: 30%–60%) underwent both studies a median of 1 week apart. The correlation between modalities was significant for PTT ( r = 0.65; P = 0.01) and normalized PTT ( r = 0.80; P = 0.001). Cardiac MRI yielded transit times consistently higher than contrast echocardiography (bias ~ 1.4 seconds), but the discordance was not dependent on transit time magnitude. Low bias was observed for comparisons of ROI size and location (<0.5 seconds). Conclusions Contrast echocardiography underestimates transit time measurements obtained by cardiac MRI , although the discrepancy was systematic and may have been contributed to by the interval between imaging studies. ROI location and size did not impact transit time values, suggesting that ROI s could be placed without intensive training, a step toward incorporation of real‐time PTT measurement into echocardiographic laboratory workflow.