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Severe mitral stenosis secondary to eosinophilic granulomatosis resolving after pharmacological treatment
Author(s) -
Szczerba Ewa,
Kowalik Robert,
Gorska Katarzyna,
Mierzejewski Michal,
Slowikowska Anna,
Bednarczyk Tomasz,
Marchel Michal,
Krenke Rafal,
Opolski Grzegorz
Publication year - 2018
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.14171
Subject(s) - medicine , granulomatosis with polyangiitis , prednisone , stenosis , eosinophilia , cardiology , cyclophosphamide , mitral valve stenosis , eosinophilic , mitral valve , surgery , ventricle , vasculitis , disease , pathology , chemotherapy
We present a case of 44‐year‐old woman who underwent effective pharmacological treatment of severe mitral stenosis. The patient was hospitalized due to rapidly progressive dyspnea. Her medical history included asthma, perennial rhinitis, and nasal polyps. Echocardiography showed a mass of the left ventricle involving the mitral valve; cardiac MRI suggested acute endocarditis. Severe peripheral blood eosinophilia was found. Eosinophilic granulomatosis with polyangiitis was diagnosed; treatment with prednisone and cyclophosphamide was started. Despite the clinical improvement, severe mitral stenosis persisted, surgical treatment was planned. However, evaluation after 6 cycles of cyclophosphamide pulse therapy revealed a significant regression of the valvular disease.