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Myocardial multilayer strain does not provide additional value for detection of myocardial viability assessed by SPECT imaging over and beyond standard strain
Author(s) -
Orloff Elisabeth,
Fournier Pauline,
Bouisset Frédéric,
Moine Thomas,
Cournot Maxime,
Elbaz Meyer,
Carrié Didier,
Galinier Michel,
Lairez Olivier,
Cognet Thomas
Publication year - 2018
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.14022
Subject(s) - nuclear medicine , receiver operating characteristic , cutoff , medicine , single photon emission computed tomography , strain (injury) , gold standard (test) , speckle tracking echocardiography , coronary angiography , cardiology , ejection fraction , heart failure , myocardial infarction , physics , quantum mechanics
Background The aim of this study was to evaluate the value of multilayer strain analysis to the assessment of myocardial viability ( MV ) through the comparison of both speckle tracking echocardiography and single‐photon emission computed tomography ( SPECT ) imaging. We also intended to determine which segmental longitudinal strain ( LS ) cutoff value would be optimal to discriminate viable myocardium. Methods We included 47 patients (average age: 61 ± 11 years) referred to our cardiac imaging center for MV evaluation. All patients underwent transthoracic echocardiography with measures of LS , SPECT , and coronary angiography. Results In all, 799 segments were analyzed. We correlated myocardial tracer uptake by SPECT with sub‐endocardial, sub‐epicardial, and mid‐segmental LS values with r = .514 P < .0001, r = .501 P < .0001, and r = .520 P < .0001, respectively. The measurements of each layer strain (sub‐endocardial, sub‐epicardial, and mid) had the same performance to predict MV viability as defined by SPECT with areas under curve of 0.819 [0.778–0.861, P < .0001], 0.809 [0.764–0.854, P < .0001], and 0.817 [0.773–0.860, P < .0001], respectively. The receiver‐operating characteristic analysis yielded a cutoff value of −6.5% for mid‐segmental LS with a sensitivity of 76% and specificity of 76% to predict segmental MV as defined by SPECT . Conclusions Multilayer strain analysis does not evaluate MV with more accuracy than standard segmental LS analysis.