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Left ventricular myocardial performance index in prediabetic patients without coronary artery disease
Author(s) -
Askin Lutfu,
Cetin Mustafa,
Tasolar Hakan,
Akturk Erdal
Publication year - 2018
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.13822
Subject(s) - prediabetes , medicine , cardiology , odds ratio , subclinical infection , coronary artery disease , diabetes mellitus , diastole , confidence interval , type 2 diabetes , endocrinology , blood pressure
Prediabetes is a high‐risk condition for diabetes mellitus type 2, which is an important public health issue. The myocardial performance index ( MPI ) is a noninvasive Doppler measurement of global ventricular function. We evaluated the MPI and left ventricular ( LV ) function in prediabetic patients who did not have coronary artery disease. Methods In total, 80 prediabetics (34 females and 46 males) and an equal number of sex‐matched healthy volunteers (35 females and 45 males) were enrolled prospectively. All subjects underwent laboratory analyses and echocardiographic examinations, including MPI measurements. Results There was a moderate increase in MPI between healthy controls and prediabetics ( P < .001). Prediabetes was strongly associated with MPI ( r = .553, P < .001). We found that MPI was associated with prediabetes on multivariate logistic regression analysis (Odds Ratio ( OR ) = 1.967, 95% confidence interval [ CI ] = 1.574–2.459, P < .001). Conclusions The results of this study show that systolic functions and LV diastolic parameters were adversely affected in prediabetic patients. Prediabetes is closely associated with subclinical LV systolic and diastolic dysfunction as assessed by MPI .