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Left ventricular mechanics are affected in children with celiac disease: A study based on two‐dimensional speckle tracking echocardiography
Author(s) -
Deveci Murat,
Uncuoğlu Aydoğan Ayşen,
Altun Gürkan,
Kayabey Özlem,
Tuğral Okan,
Babaoğlu Kadir
Publication year - 2017
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.13624
Subject(s) - medicine , speckle tracking echocardiography , tissue transglutaminase , subclinical infection , cardiomyopathy , doppler imaging , cardiology , gastroenterology , antibody , heart failure , immunology , ejection fraction , diastole , blood pressure , biochemistry , chemistry , enzyme
Background An association between cardiomyopathy and celiac disease has been reported, but not frequently. We examined the effects on cardiac mechanics in children with celiac disease (CD) by two‐dimensional speckle tracking echocardiography (2DSTE). Methods Eighty‐one children with CD were compared with a control group comprising 51 healthy children by echocardiographic examination. Children with CD who had been on gluten‐free diet for more than 6 months were divided into two different groups: group 1 was positive for serum antitissue transglutaminase antibody (n=48), and group 2 was negative for serum antitissue transglutaminase antibody (n=33). Cardiac functions were evaluated in all children using conventional echocardiography, tissue Doppler imaging (TDI), and 2DSTE methods. Results For children with CD, the mean age and male:female ratio were 10.1±4.0 years and 26/55 (67% female), respectively, which did not differ from the controls. Patients were diagnosed at a mean age of 7.9±4.1 years, and the mean follow‐up time was 2.37±2.98 years. Conventional echocardiography and TDI measurements did not differ between groups. The left ventricular longitudinal and radial strains, and strain rate values were significantly lower in patients with CD, particularly in those with positive antitissue transglutaminase antibody compared with the control group. Conclusions Our results suggest that 2DSTE is superior to conventional and TDI echocardiography for evaluating subclinical carditis in children with CD.