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Changes in right ventricular function assessed by echocardiography in dog models of mild RV pressure overload
Author(s) -
Morita Tomoya,
Nakamura Kensuke,
Osuga Tatsuyuki,
Yokoyama Nozomu,
Morishita Keitaro,
Sasaki Noboru,
Ohta Hiroshi,
Takiguchi Mitsuyoshi
Publication year - 2017
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.13560
Subject(s) - cardiology , medicine , pressure overload , speckle tracking echocardiography , pulmonary hypertension , cardiac index , hemodynamics , cardiac catheterization , pulmonary artery , cardiac output , heart failure , ejection fraction , cardiac hypertrophy
Background The assessment of hemodynamic change by echocardiography is clinically useful in patients with pulmonary hypertension. Recently, mild elevation of the mean pulmonary arterial pressure ( PAP ) has been shown to be associated with increased mortality. However, changes in the echocardiographic indices of right ventricular (RV) function are still unknown. The objective of this study was to validate the relationship between echocardiographic indices of RV function and right heart catheterization variables under a mild RV pressure overload condition. Methods and Results Echocardiography and right heart catheterization were performed in dog models of mild RV pressure overload induced by thromboxane A 2 analog (U46619) (n=7). The mean PAP was mildly increased (19.3±1.1 mm Hg), and the cardiac index was decreased. Most echocardiographic indices of RV function were significantly impaired even under a mild RV pressure overload condition. Multivariate analysis revealed that the RV free wall longitudinal strain ( RVLS ), standard deviation of the time‐to‐peak longitudinal strain of RV six segments ( RV ‐ SD ) by speckle‐tracking echocardiography, and Tei index were independent echocardiographic predictors of the mean PAP (free wall RVLS , β=−0.60, P <.001; RV ‐ SD , β=0.40, P =.011), pulmonary vascular resistance (free wall RVLS , β=−0.39, P =.020; RV ‐ SD , β=0.47, P =.0086; Tei index, β=0.34, P =.047), and cardiac index (Tei index, β=−0.65, P <.001). Conclusions Free wall RVLS , RV ‐ SD , and Tei index are useful for assessing the hemodynamic change under a mild RV pressure overload condition.