Premium
Assessment of left ventricular functions and myocardial iron load with tissue Doppler and speckle tracking echocardiography and T2* MRI in patients with β‐thalassemia major
Author(s) -
Ari Mehmet Emre,
Ekici Filiz,
Çetin İbrahim İlker,
Tavil Emine Betül,
Yaralı Neşe,
Işık Pamir,
Hazırolan Tuncay,
Tunç Bahattin
Publication year - 2017
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.13463
Subject(s) - doppler imaging , medicine , cardiology , speckle tracking echocardiography , basal (medicine) , magnetic resonance imaging , radial stress , doppler echocardiography , tissue doppler echocardiography , ejection fraction , radiology , diastole , heart failure , blood pressure , diastolic function , physics , finite element method , insulin , thermodynamics
Background The purpose of this study is to determine early myocardial dysfunction in β‐thalassemia major ( BTM ) patients. Where the myocardial dysfunction cannot be detected by conventional echocardiography, it could be detected by tissue Doppler imaging ( TDI ) or speckle tracking echocardiography ( STE ). Methods In this study, we analyzed 60 individuals, 30 of whom were BTM patients and the other 30 of whom were the control group. T2* magnetic resonance imaging ( MRI ) was used to measure cardiac iron deposition. The myocardial functions were evaluated by conventional echocardiography, TDI and STE . Results When basal lateral left ventricular and basal septal wall TDI values were compared between the patient group and control group, only isovolumic contraction time values were significantly longer in the patients. The global circumferential strain was significantly lower in the patients. When evaluated as segmental, longitudinal strain values of basal inferoseptum and circumferential strain values of anteroseptum, anterior, and inferolateral segments were significantly lower in the patients. In the patients, global longitudinal and circumferential strains in the group who had pathological T2* values were significantly lower than the group who did not. In addition, circumferential strain values in anteroseptum, anterolateral, inferior, and inferoseptum segments were significantly lower in the patients with T2* values<20 ms than those with T2* values≥20 ms. Conclusion Although T2* MRI is the most sensitive test detecting myocardial iron load, TDI and STE can be used for screening myocardial dysfunction. The abnormal strain values, especially circumferential, may be detected as the first finding of abnormal iron load and related to T2* values.