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Tricuspid annular plane systolic excursion correlates with exercise capacity in a cohort of patients with hypoplastic left heart syndrome after Fontan operation
Author(s) -
Goldberg David J.,
French Benjamin,
Szwast Anita L.,
McBride Michael G.,
Paridon Stephen M.,
Rychik Jack,
MercerRosa Laura
Publication year - 2016
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.13348
Subject(s) - medicine , cardiology , hypoplastic left heart syndrome , ventricle , excursion , coefficient of variation , cohort , reproducibility , tricuspid valve , heart disease , mathematics , statistics , political science , law
Objective Tricuspid annular plane systolic excursion ( TAPSE ) is a reproducible measure of right ventricular systolic function. We sought to determine the reliability of TAPSE measurements, to evaluate TAPSE in patients with hypoplastic left heart syndrome ( HLHS ) relative to normal values, and to correlate values of TAPSE with measures of exercise performance. Design Tricuspid annular plane systolic excursion measurements were performed off‐line in the cohort of patients with single right ventricle anatomy who had been enrolled in the Sildenafil After Fontan Operation clinical trial. These values were converted to z ‐scores using age‐specific means and standard deviations according to published reference values. Reproducibility of measurements was assessed using the coefficient of variation between two readers. Comparisons between echo measurements and exercise outcomes were assessed using Pearson correlation coefficients. Results Forty‐four echocardiograms from 11 subjects were included in this analysis. The median age of included subjects was 13 years (range 12–17). The coefficient of variation for TAPSE measurements was 5.0%. TAPSE was significantly diminished relative to reference values, with a median z ‐score of −7.6. TAPSE values correlated with both maximal oxygen consumption ( R =.64; P =.033) and oxygen consumption at the anaerobic threshold ( R =.73, P =.017). Conclusions In this small sample of children with HLHS , TAPSE was reproducible, substantially lower than reference values, and correlated well with measures of exercise performance. Further studies are needed to evaluate these findings in a larger cohort and in a longitudinal manner.