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Evaluation of P‐Wave Dispersion, Diastolic Function, and Atrial Electromechanical Conduction in Pediatric Patients with Subclinical Hypothyroidism
Author(s) -
Irdem Ahmet,
Aydın Sahin Derya,
Kervancioglu Mehmet,
Baspinar Osman,
Sucu Murat,
Keskin Mehmet,
Kilinc Metin
Publication year - 2016
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.13255
Subject(s) - medicine , subclinical infection , cardiology , diastole , doppler imaging , thyroid stimulating hormone , thyroid , blood pressure
Aim This study aimed to evaluate ventricular diastolic dysfunction, inter‐ and intraatrial conduction delay, and P‐wave dispersion in pediatric patients with subclinical hypothyroidism. Methods The study comprised a total of 30 pediatric patients with subclinical hypothyroidism ( SH ) (mean age 7.8 ± 3.2 years) and 30 healthy children (mean age 8.4 ± 3.6 years) as the control group. A SH diagnosis was made in the event of increased serum thyroid‐stimulating hormone ( TSH ) and decreased serum free triiodothyronine (T 3 ) and free thyroxine (T 4 ) concentrations. Results Conventional Doppler imaging ( TDI ) showed low mitral early diastolic E‐wave velocity and E/A ratio (P < 0.001) and significantly higher mitral late diastolic A‐wave velocity (P = 0.001) in hypothyroidism patients. Moreover, patients with hypothyroidism had significantly lower left ventricular ( LV ) septal E m velocity and E m /A m ratios compared with the control group (P < 0.001), whereas A m velocity was higher in hypothyroidism patients (P = 0.018). LV lateral E m velocity and E m /A m ratio were significantly lower in patients with hypothyroidism compared with the control group (P < 0.001). With regard to atrial electromechanical conduction, atrial electromechanical delay ( PA ) lateral, PA septum, PA tricuspid, and each of interatrial and intraatrial conduction delay were significantly prolonged in hypothyroidism patients as compared with the control group (P < 0.001, P < 0.001, P = 0.023, P = 0.002, and P = 0.003, respectively). P‐wave dispersion was significantly different in the pediatric patients with hypothyroidism (P < 0.001). Conclusion This study demonstrated atrial electromechanical conduction delay, abnormal P‐wave dispersion, and ventricle diastolic dysfunction in pediatric patients with hypothyroidism.