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Subclinical Left Ventricular Longitudinal and Radial Systolic Dysfunction in Children and Adolescents with Type 1 Diabetes Mellitus
Author(s) -
Altun Gürkan,
Babaoğlu Kadir,
Binnetoğlu Köksal,
Özsu Elif,
Yeşiltepe Mutlu Rahime G.,
Hatun Şükrü
Publication year - 2016
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.13204
Subject(s) - cardiology , medicine , ejection fraction , asymptomatic , subclinical infection , glycemic , diabetes mellitus , diastole , speckle tracking echocardiography , radial stress , heart failure , endocrinology , blood pressure , insulin , physics , finite element method , thermodynamics
There are few studies of subclinical systolic dysfunctions in children and adolescents with type 1 diabetes mellitus ( DM ), and so the available data are limited. The aim of this study was to determine early echocardiographic signs of LV systolic dysfunction in children and adolescents with type 1 DM using two‐dimensional speckle tracking echocardiography (2D STE ). Material and Methods: The study included 84 children and adolescents with type 1 DM and 32 sex‐, age‐, and body mass index–matched healthy subjects. The LV functions were assessed using conventional echocardiography, tissue Doppler imaging, and 2D STE . Results: The results showed LV diastolic dysfunction as reflected by significantly increased A‐wave velocity, decreased E/A ratio, and increased early filling deceleration time in the patients with diabetes (P = 0.02, P = 0.029, and P = 0.04; respectively). Compared with the control group, patients with diabetes showed significantly lower values for longitudinal systolic strain and strain rate in most segments of the LV ; for radial strain values of the LV ; for lateral circumferential strain and posterior and anterolateral circumferential strain rate of the LV ; and for global longitudinal and radial strain of the LV . Global longitudinal and radial strain values of the LV were significantly lower among patients with poor glycemic control than in the control group. Conclusion: In addition to diastolic dysfunction, LV longitudinal and radial function was found to be impaired in asymptomatic children and adolescents with type 1 DM who have normal LV ejection fraction by 2D STE . Glycemic control may be the main risk factor for alteration of myocardial function.