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Right Ventricular Longitudinal Strain Measures Independently Predict Chronic Heart Failure Mortality
Author(s) -
Iacoviello Massimo,
Citarelli Gaetano,
Antoncecchi Valeria,
Romito Roberta,
Monitillo Francesco,
Leone Marta,
Puzzovivo Agata,
Lattarulo Maria Silvia,
Rizzo Caterina,
Caldarola Pasquale,
Ciccone Marco Matteo
Publication year - 2016
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.13199
Subject(s) - medicine , cardiology , speckle tracking echocardiography , heart failure , ventricular function , strain (injury) , univariate analysis , multivariate analysis , ejection fraction
The assessment of right ventricular ( RV ) function still remains a challenge. Two‐dimensional (2D) speckle tracking has recently been proposed to evaluate right ventricular function by analyzing myocardial deformation. The aim of this study was to evaluate the role of 2D systolic strain measures of RV in predicting mortality in patients with chronic heart failure ( HF ). We enrolled 332 outpatients in a stable clinical condition and in conventional therapy. A right ventricular–focused four‐chamber view was analyzed by 2D speckle tracking to evaluate the global longitudinal strain of RV ( RV ‐ GLS ) and the strain of RV free wall ( RV ‐fw LS ). During a mean follow‐up of 36 ± 26 months, 64 patients died. Both RV ‐ GLS and RV ‐fw LS were associated with all‐cause mortality in univariate ( HR : 1.16; 95% CI : 1.10–1.23; P < 0.001; C‐index: 0.72; and HR : 1.10; 95% CI : 1.06–1.15; P < 0.001; C‐index: 0.68, respectively) as well as multivariate analysis ( HR : 1.13; 95% CI : 1.05–1.21; P:0.001; C‐index: 0.85; and HR : 1.07; 95% CI : 1.02–1.12; P:0.004; C‐index: 0.84, respectively). In conclusion, our findings demonstrate the role of RV 2D strain measures to independently predict mortality. These data highlight the clinical usefulness of this echocardiographic approach in the daily management of HF outpatients.