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Relation of Left Atrial Stiffness to Insulin Resistance in Obese Children: Doppler Strain Imaging Study
Author(s) -
Mahfouz Ragab A.,
Gomma Abdelaziz,
Goda Mohamed,
Safwat Mohamed
Publication year - 2015
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.12824
Subject(s) - medicine , insulin resistance , cardiology , doppler imaging , diastole , body mass index , insulin , speckle tracking echocardiography , obesity , endocrinology , blood pressure , heart failure , ejection fraction
Background The main objective of the study was to assess the strain measures (peak systolic longitudinal strain [ LAS ] and stiffness index [ LAS t]) and their relation to insulin resistance in obese children. Methods and results Eighty obese children (body mass index was 28.2 ± 3.1) and 60 age‐matched healthy nonobese children were recruited. Conventional, tissue Doppler imaging LAS and LAS t were measured for all children using 2D speckle tracking imaging (2 DSI ). Insulin resistance was assessed for obese children. Mean LAS was lower, and mean LAS t was higher in obese children as compared to control group (11.3 + 2.2 vs. 38.2 + 11.6, P < 0.001, and 1.12 ± 0.23 vs. 0.21 ± 0.11, P < 0.001, respectively). LAS t was significantly correlated with insulin resistance (P < 0.0001), and a value of >1.0 of LAS t was the best cutoff value which can predict insulin resistance in obese children with a sensitivity of 92% and specificity of 86%. Conclusions LAS and LAS t differed significantly in obese and nonobese children, in spite of normal left ventricular systolic and diastolic functions. LAS and LAS t were associated with insulin resistance in obese children.