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Pulmonary Pulse Transit Time: A Novel Echocardiographic Indicator of Hemodynamic and Vascular Alterations in Pulmonary Hypertension and Pulmonary Fibrosis
Author(s) -
Wibmer Thomas,
Rüdiger Stefan,
Scharnbeck Dominik,
Radermacher Michael,
Markovic Sinisa,
Stoiber Kathrin M.,
Rottbauer Wolfgang,
Schumann Christian
Publication year - 2015
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.12772
Subject(s) - medicine , pulmonary hypertension , hemodynamics , cardiology , vascular resistance
Pulse transit time (PTT) is generally assumed to be a surrogate marker for blood pressure changes and arterial stiffness. The aim was to evaluate whether pulmonary PTT ( pPTT ) may be noninvasively measured by Doppler echocardiography and whether it might be valuable for detecting pulmonary hemodynamic and vascular alterations. Methods We defined pPTT as the interval between R‐wave in the ECG and the corresponding peak late systolic pulmonary vein flow velocity measured by pw‐Doppler in the pulmonary vein. Twelve consecutive patients with pulmonary hypertension (PH) and 12 subjects without any cardiovascular or respiratory disease were included in the study. All patients underwent a standard echocardiography including pPTT measurement. Results In the PH group, 5 patients had idiopathic pulmonary arterial hypertension (WHO 1), 1 patient PH associated with connective tissue disease (CTD, WHO 1) without pulmonary fibrosis (PF), and 6 patients PH associated with PF either due to CTD (WHO 1) or other etiology (WHO 3). Mean pPTT was significantly shorter in the PH group (138.0 ± 16.78 msec; P < 0.0001) than in the control group (383.5 ± 23.84 msec). Within the PH group, the subgroup of patients with PF showed significantly shorter mean pPTT (93.50 ± 15.47 msec; P = 0.004) than the subgroup of patients with PH without PF (182.6 ± 14.35 msec). Conclusions The results of this study suggest that pPTT might be an interesting surrogate marker of pulmonary hemodynamic and vascular alterations in PH and PF. Further studies are warranted to evaluate the possible influence of other variables on pPTT .