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Repeatability and Agreement of Real Time Three‐dimensional Echocardiography Measurements of Left Ventricular Mass and Synchrony in Young Patients
Author(s) -
Ojala Tiina,
Mathur Sujeev,
Vatanen Anu,
Sinha Manish D.,
Jahnukainen Kirsi,
Simpson John
Publication year - 2015
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.12672
Subject(s) - repeatability , cardiology , medicine , mathematics , statistics
Background Left ventricular mass ( LVM ) and synchrony have prognostic value for many cardiovascular disease states. We report the agreement and repeatability of LVM estimation by three‐dimensional (3 D ) versus M‐mode and repeatability of 3 D estimation of systolic dyssynchrony. Methods 3 DLVM was computed by subtraction of endocardial from epicardial volume X1.05 both at end‐diastole and end‐systole. M‐mode measurements were made at end‐diastole. This prospective study comprised 40 subjects, 20 patients with chronic kidney disease or treated neuroblastoma and 20 healthy individuals. The median age was 17 (range 6–29 years). Results Intra‐ and inter‐observer intraclass correlation was excellent for 3 D systolic LVM (0.99, 0.87), 3 D diastolic LVM (0.99, 0.93), M‐mode LVM (0.88, 0.93), moderate for 16‐segment SDI (0.77, 062), moderate to low for 12‐segment SDI (0.48, 0.73), and 6‐segment SDI (0.37, 0.69). The median (range) LVM measurement for 3 D diastolic LVM was 125 g (50–253), 3 D systolic LVM 109 g (40–195), and M‐mode LVM 115 g (range 40–207). There was a significant bias for diastolic 3 DLVM to be higher than systolic 3 D or M‐mode. Limits of agreement between methods were wide. The median (range) systolic dyssynchrony measurements were 2.0 (0.4–7.0), 1.5 (0.3–4.3), and 1.4 (0.3–4.5) for 16‐segment, 12‐segment, and 6‐segment models, respectively. Conclusion 3 D and M‐mode measurement of LVM are highly repeatable. Measurement bias and wide limits of agreement mean that the same echocardiographic technique should be used during follow‐up. Measurement of 3 D systolic dyssynchrony is most repeatable using a 16‐segment model.