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Relationship of Epicardial Fat Thickness with Endothelial and Cardiac Functions in Children with Family History of Type 2 Diabetes Mellitus
Author(s) -
Mahfouz Ragab A.,
Alzaiat Ahmad,
Yousry Ahmad
Publication year - 2015
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.12595
Subject(s) - family history , medicine , diabetes mellitus , cardiology , diastole , endothelial dysfunction , body mass index , type 2 diabetes mellitus , type 2 diabetes , endocrinology , blood pressure
Objective We hypothesized that many of the pathophysiological mechanisms that cause atherosclerotic disease may be present in early childhood in children with family history of type 2 diabetes. We aimed to investigate the relation of epicardial fat thickness ( EFT ) with flow‐mediated dilatation ( FMD ) and diastolic function in children with family history of type 2 diabetes mellitus. Methods We measured EFT , FMD , in 209 children (mean age 8.6 + 3.2 years). Children were classified into 2 groups: 109 children with a family history of type 2 diabetes (group at risk) and 100 healthy children with age and body mass index matched and without parental history of diabetes constituted the control group. Results Epicardial fat thickness was significantly increased in group at risk compared with control children (P < 0.001), while FMD was significantly lower in group at risk versus controls (P < 0.001). EFT was inversely correlated with FMD (r = −0.46; P < 0.001), while it was positively correlated with E/E′ (r = 0.48; P < 0.001) and hs CRP (r = 0.39; P < 0.001). Receiver‐operating characteristic curve analysis revealed a cutoff value of 5 mm for EFT can predict endothelial dysfunction in children with family history of DM area under the curve ( AUC = 0.852) with a specificity of 92.2% and a sensitivity of 77.4%. Conclusion Our results suggest that children with family history of type 2 diabetes bear considerably impaired FMD % and diastolic dysfunction associated with increased EFT , that reflecting process that promote the development of cardiovascular disease ( CVD ).