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Double Jeopardy in the Echocardiography Laboratory: Coexistence of Two Distinct Cardiomyopathies?
Author(s) -
Paterick Timothy E.,
Tercius Alix J.,
Agarwal Anushree,
Treiber Shan C.,
Khandheria Bijoy K.,
Tajik A. Jamil
Publication year - 2014
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.12502
Subject(s) - hypertrophic cardiomyopathy , left ventricular noncompaction , cardiology , medicine , cardiac amyloidosis , cardiomyopathy , cardiac magnetic resonance , amyloidosis , concomitant , magnetic resonance imaging , heart failure , radiology
Background In our Hypertrophic Cardiomyopathy (HCM) Center, we identified 6 patients each with what appeared to be the occurrence of 2 rare diseases that prompted investigation for a common derivative. Methods We reviewed our database, searching for all patients with a diagnosis of HCM, amyloid heart disease and left ventricular noncompaction (LVNC). Results Using transthoracic echocardiography and magnetic resonance imaging, we identified 6 patients with apical hypertrabeculations and myocardium suggestive of LVNC; 4 of the patients had HCM and 2 of the patients had cardiac amyloidosis. Conclusions The significance of these possible concomitant cardiomyopathies is not presently well understood. We did not identify a common derivative when looking for a genetic link, but it is most likely hidden in the genetic substrate, yet to be identified.