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Association between Presystolic Ventricular Flash and Left Ventricular Functional Recovery after Cardiac Resynchronization Therapy
Author(s) -
Ito Takahide,
Kizawa Shun,
Nogi Shimpei,
Shimamoto Shinsaku,
Yokoyama Kaori,
Ishizaka Nobukazu
Publication year - 2014
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.12308
Subject(s) - cardiac resynchronization therapy , cardiology , medicine , ejection fraction , left bundle branch block , heart failure
The presence of septal flash ( SF ), an early inward/outward motion of the ventricular septum, has been reported to predict a fair response to cardiac resynchronization therapy ( CRT ) in patients with heart failure. Using speckle tracking echocardiography, we investigated whether the extent of pre‐ CRT SF was associated with left ventricular ( LV ) functional recovery after CRT device implantation. Fifteen patients with left bundle branch block with a mean LV ejection fraction of 23 ± 9% were enrolled in this study. The extent of presystolic ventricular flash ( PSVF ), which was defined if there was a peak in the radial strain curve in the preejection period, was semiquantified by counting the number of PSVF ‐positive segments. Patients underwent radial strain analysis before and between 3 and 6 months after CRT . After CRT device implantation, LV end‐diastolic and end‐systolic volumes were decreased, LV ejection fraction was increased, and LV filling time corrected by RR interval was increased. The number of PSVF ‐positive segments at baseline showed a graded association with improvement in both LV ejection fraction and LV filling time. In conclusion, the finding that a larger number of PSVF ‐positive segments before CRT predicted fair LV functional recovery after CRT suggests that PSVF may represent a substrate that is amenable to functional response to CRT .