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Independent Role of Left Ventricular Global Longitudinal Strain in Predicting Prognosis of Chronic Heart Failure Patients
Author(s) -
Iacoviello Massimo,
Puzzovivo Agata,
Guida Pietro,
Forleo Cinzia,
Monitillo Francesco,
Catanzaro Raffaella,
Lattarulo Maria Silvia,
Antoncecchi Valeria,
Favale Stefano
Publication year - 2013
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.12142
Subject(s) - medicine , cardiology , heart failure , heart transplantation , acute decompensated heart failure , proportional hazards model , speckle tracking echocardiography , ventricular tachycardia , ejection fraction
Aims To evaluate the independent prognostic role of two‐dimensional (2D) strain measures reflecting global longitudinal left ventricular ( LV ) systolic function in outpatients affected by chronic heart failure ( CHF ). Methods and results Global longitudinal LV systolic strain ( GLS ) was assessed in 308 outpatients affected by CHF , by analyzing standard views with 2D speckle tracking technique. During a mean follow‐up of 26 ± 13 months 37 patients died (29 due to cardiovascular causes), 10 patients underwent heart transplantation, and 75 patients experienced at least 1 episode of hospitalization due to acute decompensated heart failure ( ADHF ). Thirty‐one patients without a history of major ventricular arrhythmic events experienced the occurrence of ventricular fibrillation and/or tachycardia or sudden death was observed. Multivariate Cox regression analysis showed that GLS was significantly associated with all‐cause mortality ( HR : 1.15; 95% CI : 1.02–1.30; P: 0.026), cardiovascular death ( HR : 1.20; 95% CI : 1.04–1.39; P: 0.011), cardiovascular death or heart transplantation ( HR : 1.24; 95% CI : 1.09–1.41; P: 0.001), ADHF ‐related hospitalizations ( HR : 1.15; 95% CI : 1.05–1.25; P: 0.003), and arrhythmic events ( HR : 1.17; 95% CI : 1.03–1.33; P: 0.018). Conclusions Quantifying LV longitudinal systolic function in CHF outpatients on the basis of 2D speckle tracking analysis provides a new parameter that independently predicts patient outcome, thus, strengthening its possible role in current clinical practice.