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Relationship between Myocardial Performance Index and Severity of Coronary Artery Disease Assessed with SYNTAX Score in Stable Coronary Artery Disease
Author(s) -
Şahin Durmuş Yıldıray,
Gür Mustafa,
Elbasan Zafer,
Uysal Onur Kadir,
Özaltun Betül,
Şeker Taner,
Özkan Buğra,
Kalkan Gülhan Yüksel,
Kıvrak Ali,
Çaylı Murat
Publication year - 2013
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1111/echo.12077
Subject(s) - coronary artery disease , medicine , cardiology , ejection fraction , diabetes mellitus , coronary angiography , myocardial infarction , heart failure , endocrinology
Background The aim of the study was to investigate the relationship between severity of coronary artery disease ( CAD ) assessed with SYNTAX score ( SS ) and myocardial performance index ( MPI ) in stable CAD . Methods The study participants consisted of 106 consecutive patients (mean age: 57.6 ± 9.5 years) with angiographically proven obstructive stable CAD and 30 patients with nonobstructive CAD (control group) (mean age: 58.0 ± 7.6 years). The MPI was calculated by using pulsed‐wave D oppler before coronary angiography. Coronary angiography was performed in all patients. The SS was prospectively calculated in 106 obstructive CAD patients. Patients were partitioned into 3 groups based on SS . Frequencies of risk factors, biochemical and hematological data were recorded in all patients. Results The SS tertiles were defined as SS low ≤ 8 (n = 35), SS mid ≤ 17 (n = 36), and SS high > 17 (n = 35). The patients with SS high group (mean MPI ; 0,48 ± 0.06) based on SS had significantly higher MPI values compared with the SS mid (mean MPI ; 0,44 ± 0.05), SS low (mean MPI ; 0.43 ± 0.06), and control (mean MPI ; 0.41 ± 0.05) groups (P < 0.05 for all). The MPI levels of control group were also lower than compared with SS mid group (P = 0.006). The MPI value was significantly correlated with SS (r = 0.564, P < 0.001), diabetes (r = 0.355, P < 0.001), hypertension (r = 0.326, P < 0.001), and ejection fraction ( EF ) (r = −0.224, P = 0.018) in bivariate analysis. Multivariate regression analysis showed that MPI was independently associated with SS (β = 0.486, P < 0.001) and diabetes (β = 0.205, P = 0.028). Conclusion Although the normal EF , MPI value was impaired in proportion to the severity of CAD in patients with stable CAD .