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Predictors of overall survival in non‐small‐cell lung cancer patients with metastatic spinal cord compression treated with short‐course radiotherapy
Author(s) -
Silva Gustavo Telles,
Costa Thaís Gomes Pereira,
De Bessa Camila Martins,
Zamboni Mauro Musa,
Bergmann Anke,
Thuler Luiz Claudio Santos
Publication year - 2021
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.13427
Subject(s) - medicine , radiation therapy , proportional hazards model , lung cancer , hazard ratio , confounding , survival analysis , oncology , spinal cord compression , retrospective cohort study , performance status , cohort , overall survival , surgery , spinal cord , confidence interval , psychiatry
Metastatic spinal cord compression (MSCC) is a condition that impacts directly on the patient's prognosis. Objective The study purpose was to identify predictors of overall survival in non‐small‐cell lung cancer (NSCLC) patients with MSCC. Methods A cohort study involving NSCLC patients enrolled between 2008 and 2017 was performed. Sixty‐four patients treated with short‐course radiotherapy were included. Clinical and socio‐demographic data were extracted from medical records. Data were analysed using survival analysis and Cox proportional hazard regression analysis. Results The median survival time was 2.5 months (95% CI: 1.6–3.5). Patients >60 years had shorter survival than younger patients (HR 1.85; 95% CI 1.06–3.24; p = 0.02), and patients with performance status (PS) >2 had shorter survival than those with PS≤2 (HR 1.93; 95% CI 1.12–3.33; p = 0.01). Conclusion This study found worse PS and higher age are independent predictors of overall survival in NSCLC patients with MSCC treated with short‐course radiotherapy after adjusting the potential confounding factors (PS, age and target therapy).