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Factors associated with colon cancer early, intermediate and late recurrence after surgery for stage I–III: A 5‐year prospective study
Author(s) -
Orive Miren,
Anton Ane,
Gonzalez Nerea,
Aguirre Urko,
Anula Rocío,
Lázaro Santiago,
Redondo Maximino,
Bare Marisa,
Briones Eduardo,
Escobar Antonio,
Sarasqueta Cristina,
Ferreiro Josefa,
Quintana José M.
Publication year - 2020
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.13317
Subject(s) - medicine , stage (stratigraphy) , perforation , colorectal cancer , chemotherapy , lymph node , odds ratio , surgery , cancer , gastroenterology , paleontology , biology , materials science , metallurgy , punching
Objective To identify factors associated with early, intermediate or late recurrence colon cancer recurrence. Methods A total of 1,732 consecutive patients with colon cancer were recruited and followed for a period of 5 years. Recurrence at 1 year (early), from 1 to 2 (early), from 2 to 3 (intermediate) and from 3 to 5 years (late) was the main outcome measures. Results Predictors of early recurrence (AUC (95% CI):0.74 (0.70–0.78) were as follows: TNM stage II and III, more than one type of invasion, haemoglobin <10 g/dl, residual tumour (R1), ASA IV, log odds of positive lymph nodes ratio ≥−0.53, perforation, neoadjuvant chemotherapy, infectious complications within 1 year and CEA pre‐ and post‐intervention. These factors remained significant for predicting intermediate (AUC [95% CI]: 0.72 [0.67–0.77]) and late (AUC [95% CI]: 0.68 [0.63–0.74]) recurrence, except for ASA class, log lymph node ratio, perforation and neoadjuvant chemotherapy. Additionally, laterality (left) and medical complications up to 2 years were significant. Conclusions These risk factors show good predictive ability of early, intermediate and late recurrence, confirming factors established by guidelines and adding some others. They could serve to provide more appropriate and accurate treatment and follow‐up tailored to patient characteristics.