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Health‐related quality of life in long‐term survivors with localised prostate cancer by therapy—Results from a population‐based study
Author(s) -
Adam Salome,
KochGallenkamp Lena,
Bertram Heike,
Eberle Andrea,
Holleczek Bernd,
Pritzkuleit Ron,
WaldeyerSauerland Mechthild,
Waldmann Annika,
Zeissig Sylke Ruth,
Rohrmann Sabine,
Brenner Hermann,
Arndt Volker
Publication year - 2019
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.13076
Subject(s) - medicine , quality of life (healthcare) , prostate cancer , androgen deprivation therapy , radiation therapy , prostatectomy , population , cancer , physical therapy , nursing , environmental health
Objective Several therapies for localised prostate cancer (PC) are available; all yield similar survival rates. However, each therapy has significant side effects that can influence patients' health‐related quality of life (HRQoL) in the long run. Methods The study sample included 911 survivors with localised PC, 5–15 years post‐diagnosis who were identified from the population‐based CAESAR + study in Germany. HRQoL was assessed using the EORTC QLQ‐C30 and EORTC QLQ‐PR25 questionnaires. The association between type of therapy and HRQoL was assessed with multivariable linear regression and global F‐test adjusting for age, time since diagnosis and comorbidities. Results Overall, survivors treated with radical prostatectomy (RP) or radiotherapy (RT) alone reported the best HRQoL and the lowest symptom burden. Conversely, survivors treated with androgen deprivation therapy (ADT) (& RP/RT) or RP & RT (in combination) reported the worst HRQoL and the highest symptom burden. Significant differences among treatment groups in HRQoL were found for global health status ( p = 0.041), social functioning ( p = 0.007), urinary symptoms ( p = 0.035), bowel symptoms ( p = 0.017) and hormonal treatment‐related symptoms ( p < 0.001) among other symptoms. Conclusions Long‐term localised PC survivors formerly treated with a combination of RP and RT or with ADT report poorer HRQoL and more symptoms than patients treated with either RP or RT alone.