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Health‐related quality of life in AYA cancer survivors who underwent HSCT compared with healthy peers
Author(s) -
Tremolada Marta,
Bonichini Sabrina,
Taverna Livia,
Basso Giuseppe,
Pillon Marta
Publication year - 2018
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.12878
Subject(s) - medicine , quality of life (healthcare) , hematopoietic stem cell transplantation , young adult , intrusion , physical therapy , pediatrics , transplantation , nursing , geochemistry , geology
Abstract This study was aimed at comparing adolescent and young adult (AYA) Hematopoietic Stem Cell Transplantation (HSCT) paediatric cancer survivors and a control group of healthy peers in terms of Health‐Related Quality of Life (HRQOL) and frequency of posttraumatic stress symptoms (PTSS). The participants were 32 AYA HSCT survivors and 28 matched healthy peers. The survivors were, on average, 19.4 years old ( SD = 3.8), with an average age of 8.1 years ( SD = 4.3) at diagnosis, and with a mean time, since treatment was completed, of 8.5 years ( SD = 3.2). The majority of survivors (78.1%) did not show clinical PTSS, with intrusion symptoms most frequently reported in those who had undergone autologous HSCT ( F = 3.3; df = 2; p = 0.05) and relapse presence in their treatment associated with more PTSS avoidance symptoms ( r = 0.4; p = 0.002). Women reported more problems in the SF‐36 pain scale ( t = 2.1; df = 31; p = 0.04) than men. Additionally, 87.5% of survivors fell below the 25th percentile in the SF‐36 general well‐being scale, and 70.8% had the same trend for the SF‐36 fatigue scale. Survivors reported better emotional well‐being ( t = 2.6, df = 27, p = 0.01) and fewer limitations than their healthy peers ( t = 2.5, df = 27, p = 0.02), while they perceived a lower life satisfaction referring to the past ( t = −2.8, df = 27, p = 0.009).