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Changes in metabolic risk, insulin resistance, leptin and adiponectin following a lifestyle intervention in overweight and obese breast cancer survivors
Author(s) -
Travier Noemie,
Buckland Genevieve,
Vendrell Joan J.,
FernandezVeledo Sonia,
Peiró Immaculada,
del Barco Sonia,
Pernas Sonia,
Zamora Esther,
Bellet Meritxell,
Margeli Mireia,
Cirauqui Beatriz,
Muñoz Montserrat,
Tusquets Ignasi,
Arcusa Angels,
Javierre Casimiro,
Moreno Ferran,
Rodriguez Ana,
Agudo Antonio
Publication year - 2018
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.12861
Subject(s) - medicine , adiponectin , insulin resistance , leptin , overweight , adipokine , cardiorespiratory fitness , obesity , anthropometry , breast cancer , endocrinology , body mass index , metabolic syndrome , insulin , oncology , cancer
Adiposity and physical activity are modifiable factors that could be important determinants of breast cancer ( BC ) prognosis through their effects on endogenous reproductive hormones, chronic inflammation and metabolic changes. Therefore, it is necessary to evaluate whether offering lifestyle interventions to BC survivors could affect the levels of certain biomarkers involved in these mechanisms. We designed a pre–post intervention study offering diet and exercise sessions over 12 weeks to 42 overweight/obese BC survivors. Before and after the intervention, we obtained dietary information, anthropometry and cardiorespiratory fitness ( CRF ) measurements and blood samples to measure metabolic risk, insulin resistance and adipokines biomarkers. Wilcoxon signed‐rank tests and Spearman partial correlation coefficients were used to compare pre‐ and post‐measurements and assess the correlations between changes in biomarkers and changes in anthropometry and CRF . Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non‐significant leptin decrease and a significant adiponectin decrease. The improvements in metabolic risk biomarkers, insulin resistance indicators and leptin were moderately correlated (0.32 ≤ | r | ≤ 0.55) with the decrease in body mass index and the increase in CRF . Diet and exercise interventions implemented in overweight/obese BC survivors may improve metabolic risk, insulin resistance and leptin biomarkers.