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Ovarian response to controlled ovarian stimulation for fertility preservation before oncology treatment: A retrospective cohort of 157 patients
Author(s) -
Tsampras Nikolaos,
Roberts Stephen A.,
Gould Della,
Fitzgerald Cheryl T.
Publication year - 2018
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.12797
Subject(s) - medicine , fertility preservation , infertility , retrospective cohort study , gynecology , cohort , fertility , ovarian hyperstimulation syndrome , incidence (geometry) , gynecologic oncology , assisted reproductive technology , oocyte , oncology , in vitro fertilisation , pregnancy , population , embryo , physics , environmental health , biology , optics , genetics , microbiology and biotechnology
This is a retrospective cohort study aiming to examine the response of oncology patients undergoing controlled ovarian stimulation ( COS ) for fertility preservation and to review the incidence of short‐term complications. The study group consisted by all oncology patients undergoing ovarian stimulation for fertility preservation ( n = 157) between April 2009 and April 2016. Patients undergoing COS for IVF / ICSI for male factor only infertility in the same time period ( n = 2,128) provided a comparator group. Oncology patients underwent COS to retrieve eggs for storage and future use. The cancer patients had a very similar distribution of oocyte yield to the comparator group. Those with ovarian cancer did have significantly lower oocyte recovery than those with other cancers (age‐adjusted difference 7, 95% CI : 2–12). None of the patients in the study group were admitted with ovarian hyperstimulation syndrome or any other complication of COS or oocyte retrieval. This is one of the largest reported cohorts of patients treated for fertility preservation before oncology treatment. Our data have demonstrated a good response to stimulation, offering a reasonable chance of pregnancy in the future. In contrast to previous studies, we have demonstrated a similar number of oocytes retrieved to that of women undergoing IVF / ICSI treatment for male factor infertility.