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Effect of aerobic exercise intervention on markers of insulin resistance in breast cancer women
Author(s) -
Bruno E.,
Roveda E.,
Vitale J.,
Montaruli A.,
Berrino F.,
Villarini A.,
Venturelli E.,
Gargano G.,
Galasso L.,
Caumo A.,
Carandente F.,
Pasanisi P.
Publication year - 2018
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.12617
Subject(s) - medicine , aerobic exercise , breast cancer , insulin resistance , resistance training , intervention (counseling) , cancer , oncology , physical therapy , insulin , nursing
Insulin may affect breast cancer ( BC ) risk and prognosis. Exercise reduces insulin in obese BC survivors. We designed a randomised controlled trial to test the effect of an aerobic exercise intervention ( AEI ) on insulin parameters and body composition in non‐obese BC women without insulin resistance. Thirty‐eight BC women were randomised into an intervention group ( IG = 18) or control group ( CG = 20). IG participated in a structured AEI for 3 months, while CG received only the Word Cancer Research Fund/American Institute Cancer Research ( WCRF / AICR ) recommendation to be physically active . Fasting insulin, homeostasis model assessment of insulin resistance ( HOMA ‐ IR ) index, metabolic parameters and body composition were collected at baseline and after the AEI . IG reduced insulin and HOMA ‐ IR index by 15% and 14%, while CG increased these parameters (+12% and +16%). Insulin changed differently over time in the two randomised groups ( p interaction = .04). The between‐group differences in the change of insulin ( IG = −1.2 μU/ml versus CG = +0.8 μU/ml) and HOMA ‐ IR index ( IG = −0.26 versus CG = +0.25) were respectively significant ( p = .04) and non‐significant ( p = .06). IG significantly improved lower limb muscle mass in comparison with CG ( p = .03). A structured AEI may improve insulin, HOMA ‐ IR index and body composition in non‐obese BC survivors without insulin resistance.