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Prognostic significance of standardised uptake value ( SUV max ) measured on 18F‐fluorodeoxyglucose positron emission tomography/computed tomography in patients with small cell lung cancer
Author(s) -
Yilmaz Demirci N.,
Yilmaz Ü.,
Biner Uslu İ.,
Dikmen A.,
Yılmaz A.,
Erdoğan Y.
Publication year - 2017
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.12485
Subject(s) - medicine , positron emission tomography , lung cancer , positron emission tomography computed tomography , fluorodeoxyglucose , standardized uptake value , nuclear medicine , computed tomography , positron emission , radiology , tomography , oncology
Certain prognostic factors for small cell lung cancer ( SCLC ) have been validated, but the prognostic role of 18F‐ FDG PET / CT still remains unclear. The aim of this study was to evaluate the prognostic significance of 18F‐ FDG PET / CT in patients with SCLC . We reviewed 142 patients with pathologically proven SCLC who underwent pre‐treatment 18F‐ FDG PET / CT . Standardised uptake value (SUV max ) and other potential prognostic variables were chosen for analysis. The mean age of the study population was 58.2 ± 10.1 years (range, 25–84), and 124 (87.3%) patients were men. The median SUV max value was 11.6 (4.0–29.3). Among the variables included in the univariate analysis, performance status ( P = 0.001), disease stage ( P < 0.001), administration of thoracic radiotherapy (TRT; P < 0.001), albumin level ( P = 0.030) and LDH level ( P < 0.001) showed prognostic significance. Further, multivariate analysis showed that performance status ( P = 0.007), albumin level ( P = 0.002), LDH level ( P < 0.001) and administration of TRT ( P = 0.001) were independent prognostic factors for survival. In conclusion, performance status, TRT, LDH level and albumin level were identified as important prognostic factors, while 18F‐ FDG PET / CT uptake of the primary lesions did not have any prognostic significance for survival in patients with SCLC .