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Tumour‐associated antigens and their anti‐cancer applications
Author(s) -
Liu C.C.,
Yang H.,
Zhang R.,
Zhao J.J.,
Hao D.J.
Publication year - 2017
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.12446
Subject(s) - medicine , antigen , cancer , heat shock protein , cancer research , immunology , oncology , gene , biology , genetics
So far, a number of tumour‐associated antigens ( TAA s), such as heat shock proteins, alpha‐fetoprotein, carcino‐embryonic antigen and others have been identified in a variety of malignant tumours. Differences in the expression levels of TAA s in cancers compared with normal cells have led to these antigens being investigated as diagnostic and prognostic biomarkers or exciting targets in cancer treatment. Here, we systematically list the current representative TAA s to shed some light on current approaches and challenges for their anti‐cancer application in cancer therapy. In this review, we discuss the ongoing pre‐clinical studies and clinical development of TAA s in human cancers, and the potential application of these TAA s in the diagnosis and prognosis for cancer treatment.