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Incidence and risk of peripheral neuropathy with nab‐paclitaxel in patients with cancer: a meta‐analysis
Author(s) -
Peng L.,
Bu Z.,
Ye X.,
Zhou Y.,
Zhao Q.
Publication year - 2017
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.12407
Subject(s) - medicine , peripheral neuropathy , paclitaxel , incidence (geometry) , meta analysis , cancer , oncology , peripheral , clinical trial , confidence interval , gastroenterology , endocrinology , physics , optics , diabetes mellitus
Nab‐paclitaxel, a Cremophor EL ‐free formulation of paclitaxel, is used to treat various malignancies. Peripheral neuropathy is one of its major toxicities, although the overall incidence remains unclear. We performed a meta‐analysis to calculate the incidence of peripheral neuropathy in cancer patients treated with nab‐paclitaxel and to compare the relative risk ( RR ) with conventional taxanes. The electronic databases were searched for relevant clinical trials. Eligible studies included phase II and III prospective clinical trials of cancer patients treated with nab‐paclitaxel with toxicity profile on peripheral neuropathy. Statistical analyses were done to calculate summary incidences, RR s and 95% confidence intervals ( CI ), using fixed‐effects or random‐effects models based on the heterogeneity of the included studies. Nineteen trials were selected for the meta‐analysis, yielding a total of 2878 cancer patients. The overall incidences of peripheral neuropathy (all‐grade) was 51.0% (95% CI : 45.1–57.6%), and that of high‐grade peripheral neuropathy was 12.4% (9.8–15.7%). The RR s of peripheral neuropathy of nab‐paclitaxel compared to taxanes were not increased for all‐grade and high‐grade peripheral neuropathy. Nab‐paclitaxel is associated with an increased risk of developing peripheral neuropathy. Future clinical studies are still needed to investigate the risk reduction and possible use of nab‐paclitaxel.