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Prognostic implications of RB 1 tumour suppressor gene alterations in the clinical outcome of human osteosarcoma: a meta‐analysis
Author(s) -
Ren W.,
Gu G.
Publication year - 2017
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.12401
Subject(s) - osteosarcoma , medicine , funnel plot , meta analysis , cochrane library , oncology , publication bias , retinoblastoma , metastasis , chemotherapy , cancer , cancer research , gene , biochemistry , chemistry
Primary osteosarcoma is the most frequent malignant bone cancer in children and teenagers. Genetic alterations at the retinoblastoma 1 ( RB 1 ) gene has been implicated in the development and progression of human osteosarcoma. Here, we performed a meta‐analysis to examine the impact of RB 1 mutations on the survival of osteosarcoma patients, the risk of metastasis and the histological response of osteosarcoma to chemotherapy. A systemic review of the Medline, Embase, Scopus and Cochrane Library yielded 12 eligible studies with 491 patients for this study. Forest plots resulting from our meta‐analyses illustrate that loss of RB 1 function results in a 1.62‐fold increase in the mortality rate for osteosarcoma patients ( RR = 1.62, 95% CI : 1.23–2.13; Z = 3.44, P = 0.0006), a significant increase in osteosarcoma metastasis ( OR = 3.95, 95% CI : 1.86–8.38; Z = 3.57; P = 0.0004), and a significant reduction in the histological response of osteosarcoma to chemotherapy ( OR = 0.35; 95% CI : 0.13–0.94; Z = −2.08; P = 0.038). Additionally, the nearly symmetrical funnel plot (Egger's test, t = 1.15, P = 0.288) indicates absence of publication bias regarding the meta‐analysis that examined the correlation of RB 1 alterations with the survival rate for osteosarcoma patients. Our findings suggest that RB 1 alterations may serve as a prognostic marker for the management of osteosarcoma patients.