Premium
Do we have predictors of therapy responsiveness for a multimodal therapy concept and aerobic training in breast cancer survivors with chronic cancer‐related fatigue?
Author(s) -
Kröz M.,
Reif M.,
Zerm R.,
Winter K.,
Schad F.,
Gutenbrunner C.,
Girke M.,
Bartsch C.
Publication year - 2015
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.12278
Subject(s) - medicine , cancer related fatigue , physical therapy , quality of life (healthcare) , pittsburgh sleep quality index , breast cancer , cancer , psychological intervention , intervention (counseling) , psychiatry , sleep quality , cognition , nursing
C ancer‐related fatigue ( CRF ) is a burdensome symptom for breast cancer ( BC ) patients. In this pilot study, we tested several questionnaires as predictors for treatment responsiveness, along with the implementation of a multimodal therapy concept consisting of sleep, psycho‐education, eurythmy, painting therapy and standard aerobic training. At the C ommunity H ospital H avelhöhe and the H annover M edical S chool, 31 BC patients suffering from CRF could be evaluated in a 10‐week intervention study. CRF was assessed by the C ancer F atigue S cale ( CFS ‐ D ). Further questionnaires were the P ittsburgh S leep Q uality I ndex, the autonomic regulation scale, S elf‐ R egulation S cale ( SRS ), the I nternal C oherence S cale ( ICS ) and the E uropean O rganization of R esearch and T reatment Health‐Related Q uality of L ife C ore Q uestionnaire scale. We estimated the regression coefficients of all scales on CFS ‐ D by simple and multiple linear regression analyses and compared regression slopes and variances between the different questionnaires on CFS ‐ D at the end of treatment. We found a significant impact of SRS and ICS at baseline on CFS ‐ D at the end of the intervention [absolute standardised multiple regression coefficient values ranging from 0.319 ( SRS ) to 0.269 ( ICS )] but not for the other questionnaires. In conclusion, this study supports the hypothesis that the SRS or ICS measuring adaptive capacities could be more appropriate as outcome predictors than classical questionnaire measures in complex interventions studies.