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Effects of exercise on angiogenesis and apoptosis‐related molecules, quality of life, fatigue and depression in breast cancer patients
Author(s) -
Ergun M.,
Eyigor S.,
Karaca B.,
Kisim A.,
Uslu R.
Publication year - 2013
Publication title -
european journal of cancer care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 67
eISSN - 1365-2354
pISSN - 0961-5423
DOI - 10.1111/ecc.12068
Subject(s) - medicine , depression (economics) , angiogenesis , breast cancer , quality of life (healthcare) , beck depression inventory , physical therapy , cancer related fatigue , cancer , oncology , anxiety , psychiatry , nursing , economics , macroeconomics
The aim of this study was to explore the effects of exercise on angiogenesis and apoptosis‐related molecules, quality of life, fatigue and depression in patients who completed breast cancer treatment. Sixty breast cancer patients were randomised into three groups, as supervised exercise group, home exercise group and education group. Angiogenesis and apoptosis‐related cytokine levels and quality of life ( EORTC QOL ‐ C 30: E uropean O rganisation for R esearch and T reatment of C ancer Q uality of L ife C 30), fatigue ( B rief F atigue I nventory) and depression ( BDI : Beck Depression Inventory) scores were compared before and after a 12‐week exercise programme. After the exercise programme, statistically significant decreases were found in interleukin‐8 and neutrophil activating protein‐78 levels in the home exercise group ( P < 0.05). The education group showed a statistically significant increase in monocyte chemoattractant protein‐1 level ( P < 0.05). Functional score and global health score of EORTC QOL ‐ C 30 in the supervised exercise group and functional score of EORTC QOL ‐ C 30 in the home exercise group increased significantly after exercise programme ( P < 0.05). BDI score was significantly lower in the supervised exercise group after the exercise programme ( P < 0.05). Changes in angiogenesis and apoptosis‐related molecules in the study groups suggest a possible effect of exercise on these parameters. Exercise programmes are safe and effective on quality of life and depression in breast cancer patients whose treatments are complete.