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A daily regimen of a ceramide‐dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: A randomized trial
Author(s) -
Spada Fabrizio,
Harrison Ian P.,
Barnes Tanya M.,
Greive Kerryn A.,
Daniels Daisy,
Townley Joshua P.,
Mostafa Niyaz,
Fong Andrew T.,
Tong Philip L.,
Shumack Stephen
Publication year - 2021
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.14970
Subject(s) - medicine , cleanser , transepidermal water loss , placebo , adverse effect , moisturizer , dry skin , sensitive skin , ceramide , atopic dermatitis , stratum corneum , dermatology , randomized controlled trial , regimen , skin barrier , mometasone furoate , dermatology life quality index , corticosteroid , pathology , psoriasis , apoptosis , biochemistry , chemistry , alternative medicine , food science
The dysfunctional skin barrier in eczema patients may be attributed to decreased levels of ceramides in the stratum corneum. The aim of this study was to determine whether a two‐part system consisting of a ceramide‐dominant physiological lipid‐based moisturizing cream and cleanser could ameliorate the signs and symptoms of moderate eczema in adults over 28 days compared to placebo. Assessments were conducted at baseline and every 7 days thereafter. Eczema area severity index score decreased significantly across all time points in both groups compared to baseline ( P < .0001), however, this decrease was not significant between groups at day 28 ( P = .7804). In contrast, transepidermal water loss and skin hydration significantly improved over time in the active group, while it either stayed the same or worsened in the placebo group ( P = .0342 and P < .0001, respectively). There was no difference in the use of mometasone furoate as rescue medication over time between groups ( P = .1579). Dermatology life quality index scores improved significantly in both groups ( P < .0001), with no difference between groups ( P = .5256). However, patient satisfaction was greater in the active compared to the placebo group for several parameters including relief of itch, dry skin, skin softness and smoothness (all P < .05). No patients withdrew from the study due to adverse events (AEs) and there were no serious AEs. The ceramide‐dominant moisturizing cream and cleanser safely restores skin permeability and improves the signs and symptoms of eczema in adults.