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CD4 + T cells apoptosis and conversion of Th1/Th2‐type cytokines promote the progress of sporotrichosis
Author(s) -
Ji YongZhi,
Mei XiangLin,
Jia LiLi,
Liu ShiRui
Publication year - 2021
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.14720
Subject(s) - sporotrichosis , apoptosis , immunology , cytokine , sporothrix schenckii , medicine , immunity , cd4 t cell , t cell , immune system , biology , genetics
Sporotrichosis is a fungal disease of the human and other mammals, caused by a complex of Sporothrix schenckii . The disease follows the traumatic inoculation to lead to fixed lesions, regional lymphangitic lesions, or even disseminated lesions including internal involvement, which depends on host immunological status and strain virulence. In this work, we observed the role of CD4 + T cells apoptosis and conversion of Th1/Th2‐type cytokines in the cellular immunity regulation on mice model sporotrichosis. The experiments showed that there was more CD4 + T cells apoptosis, by endogenous apoptosis signaling pathway ( P < .05), and more conversions of Th1/Th2‐type cytokines in more severe and longer duration groups ( P < .05). Meanwhile, the trends of the conversions of Th1/Th2‐type cytokines were almost consistent with the CD4 + T cell's apoptosis in the corresponding groups. These findings suggest that CD4+ T cells apoptosis and conversion of Th1/Th2‐type cytokines are contributing to promoting the progress of sporotrichosis.