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Correlation of urticaria activity score in chronic spontaneous urticaria with serum C‐reactive protein level and neutrophil/lymphocyte ratio
Author(s) -
Akca Hanife Merve,
Tuncer Kara Kevser
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.14532
Subject(s) - medicine , erythrocyte sedimentation rate , neutrophil to lymphocyte ratio , chronic urticaria , c reactive protein , gastroenterology , lymphocyte , inflammation , thyroglobulin , endocrinology , immunology , thyroid
Chronic spontaneous urticaria (CSU) lacks a specific trigger. The urticaria activity score (UAS) is used to evaluate disease status. Some studies have reported elevated serum levels of high‐sensitivity C‐reactive protein (hsCRP) in CSU patients, which is correlated with disease severity. The neutrophil/lymphocyte (N/L) ratio is a significant indicator of systemic inflammation. We investigated the potential correlation between serum levels of hsCRP and N/L ratio, as well as urticaria activity, in CSU patients. We included 52 CSU patients treated at the Dermatology Polyclinic of Beysehir State Hospital between August and October 2020, and 50 controls. The 7‐day UAS were graded mild, moderate, or intense. We measured N/L ratios, erythrocyte sedimentation rates (ESRs), and the levels of hsCRP, T4, and thyroid‐stimulating hormone (TSH) in each group. The anti‐thyroglobulin (anti‐TG) and anti‐microsomal antibody (anti‐TPO) levels of CSU patients were also assayed. There were no significant differences in hsCRP, T4, or TSH levels between the groups; however, both the ESR and N/L ratio were significantly higher in CSU patients hsCRP ( P = .96), T4 ( P = .07), TSH ( P = .67), ESR ( P < .001), N/L( P < .001). No correlation was evident between the UAS day 7 (UAS7) score and the hsCRP level or the N/L ratio ( P = .528 and P = .387). Of all the CSU patients, 19.2% tested positive for anti‐TPO and 9.6% were positive for anti‐TG; these data were not correlated with the UAS7 ( P = 1 and P = .637). Inflammation plays a role in CSU. Although we did not find a correlation between the UAS and either the hsCRP level or the N/L ratio, the ESR and N/L ratio were higher in CSU patients than in controls.