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Comparative evaluation of topical diclofenac sodium versus topical ibuprofen in the treatment of seborrheic keratosis
Author(s) -
Afify Ahmed Abdelfattah,
Hana Mariam Raoof
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.14370
Subject(s) - medicine , diclofenac sodium , seborrheic keratosis , diclofenac , dermatology , ibuprofen , keratosis , lesion , significant difference , surgery , pharmacology
In 2016, a case of seborrheic keratosis was successfully treated with diclofenac gel 3%. Diclofenac gel mechanism of action is most likely through induction of apoptosis. This study included 30 patients with multiple seborrheic keratosis. One lesion was treated with topical diclofenac sodium gel 1% and another lesion with topical ibuprofen gel applied twice daily for 8 weeks. Adobe photoshop CS6 was used to measure the surface area of the lesions before treatment and after 8 weeks. There was a highly statistically significant difference in the surface area of the lesions before and after treatment with topical diclofenac 1% gel ( P = .001) but there was no statistically significant difference with topical ibuprofen gel ( P = .057). There was a highly significant difference between the two treatment regimens as regard the percentage of change in surface area of the lesions, with higher change in the diclofenc 1% gel‐treated group ( P = .001). No patients complain from any side effect from either treatment.