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Efficacy of oral supplementation of whey protein in patients with contact dermatitis: A pilot randomized double‐blind placebo‐controlled clinical trial
Author(s) -
Alyasin Soheila,
Nabavizadeh Seyed Hesamedin,
Esmaeilzadeh Hossein,
Heydari Seyed Taghi,
Mosavat Seyed Hamdollah,
Parvizi Mohammad Mahdi,
Hashemi Seyyed Mohammad,
Hashempur Mohammad Hashem
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.14260
Subject(s) - medicine , placebo , visual analogue scale , dermatology life quality index , randomized controlled trial , whey protein , quality of life (healthcare) , clinical trial , placebo controlled study , eczema area and severity index , physical therapy , double blind , disease , pathology , food science , alternative medicine , chemistry , nursing
Abstract Whey protein is a popular dietary product that has numerous health benefits such as immune modulation. In this study, we assessed efficacy of whey protein in management of patients with contact dermatitis (CD) through a double blind, randomized controlled clinical trial in Emam Reza clinic, Shiraz, Iran. Twenty‐five patients in each group were randomly assigned to receive whey protein or placebo powder, 30 g in 200 mL warm water at fasting time for 4 weeks. Outcome measures were Dermatology Life Quality Index (DLQI) questionnaire and the Eczema Area and Severity Index (EASI) score. Furthermore, subjective total improvement (assessed by visual analogue scale) was set as the other primary outcome measure. A significant decrease was observed in the scores of EASI, DLQI, and subjective total improvement in the drug group after the intervention compared with the baseline. However, no changes were seen in the placebo group. Moreover, there was a significant reduction in the scores of EASI ( P = .002) and subjective total improvement scores ( P = .039) over the study period in the drug group compared with the placebo group. According to the results of this study, it seems that oral supplementation of whey protein could improve the symptoms of CD compared with placebo.