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Efficacy of Lobelia alsinoides Lam ethanolic extract on a third‐degree burn: An experimental study on rats
Author(s) -
Samdavid Thanapaul Rex Jeya Rajkumar,
Ranjan Abraham,
Manikandan Sreeraj K.,
Nadar M. S. A. Muthukumar
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.14242
Subject(s) - medicine , eschar , wound healing , traditional medicine , burn wound , second degree burn , silver sulfadiazine , pharmacology , surgery
This is the first study to evaluate the topical application of Lobelia alsinoides Lam (LT) ethanolic extract on burns in rats. A deep third‐degree burn wound was inflicted in adult male Wistar rats and the burns were dressed daily with a topical ointment formulation (Patent filed) comprising of Lobelia alsinoides Lam (5% and 10% w/w). The wound had noteworthy contraction and quicker eschar removal in 10% w/w LT‐treated groups followed by 5% w/w treated groups on comparing with the commonly prescribed ointment (Silverex TM containing 1% w/w Silver sulfadiazine). Histopathological analysis showed that ointment containing 10% w/w LT ethanolic extract significantly increased fibroblast growth, which plays a major role in anatomic integrity, collagen synthesis, and accelerated the rate of the healing process. This study shows that the ethanolic extract of Lobelia alsinoides Lam , a previously pharmacologically unreported traditional medicinal plant, possesses wound contraction and eschar removal properties on burn wounds.