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Insightful exploring of microRNAs in psoriasis and its targeted topical delivery
Author(s) -
Pradyuth Sai,
Rapalli Vamshi Krishna,
Gorantla Srividya,
Waghule Tejashree,
Dubey Sunil Kumar,
Singhvi Gautam
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.14221
Subject(s) - psoriasis , microrna , medicine , immune system , gene silencing , bioinformatics , computational biology , immunology , biology , gene , genetics
Psoriasis is a common immune‐mediated inflammatory skin disease. It includes multifaceted interaction between the immune system and the keratinocytes. Recent studies depicted the role of microRNAs (miRNAs) in hyperproliferation of keratinocytes and inflammatory cytokine production, which serve as biomarkers for diagnosis, monitoring treatment response, and prognosis. miRNAs are small nucleotide sequenced noncoding RNAs. Deregulation of miRNAs was found to be the most common factor in the studies pertaining to psoriasis. Hence, miRNA‐based targeting for psoriasis treatment became the primary field of current research. miRNA due to its spatial and chemical properties offer different challenges in the process of its delivery. The topical delivery of different siRNAs and genes has paved a way to similar delivery of miRNA. The topical delivery of miRNAs to the skin can bring a revolutionary change in the field of psoriasis treatment.