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Network pharmacology‐based identification for therapeutic mechanisms of Dangguikushen pill in acne vulgaris
Author(s) -
Yu Bo,
Diao NanNan,
Zhang Ying,
Li XingZi,
Yu Ning,
Ding YangFeng,
Shi YuLing
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.14061
Subject(s) - kegg , acne , pi3k/akt/mtor pathway , medicine , pill , computational biology , wnt signaling pathway , biological pathway , signal transduction , protein kinase b , bioinformatics , pharmacology , traditional medicine , biology , transcriptome , gene , genetics , gene expression , dermatology
The Dangguikushen (DGKS) pill is a proprietary traditional Chinese medicine that has shown superior efficacy in the treatment of acne vulgaris for many years. A network pharmacology‐based analysis was performed to explore the potential anti‐acne compounds, core therapeutic targets, and the main pathways, involved in the DGKS pill bioactivity. The matching results between the predicted targets of the DGKS pill and the well‐known targets of acne vulgaris were collected, followed by network establishment using protein‐protein interaction (PPI) data. Cytoscape was utilized to analyze the network and screen the core targets. Furthermore, the Database for Annotation, Visualization and Integrated Discovery (DAVID), and ClueGO were used for the enrichment analysis of the Kyoto Encyclopedia of Genes and Genomics (KEGG) pathways and Gene Ontology biological processes (GO‐BP). Finally, the “compound‐target‐pathway” network was constructed. This approach identified 19 active compounds, 46 therapeutic targets, and 12 core therapeutic targets of the DGKS pill. The biological processes were primarily related to reactive oxygen species (ROS) metabolic process, gland morphogenesis, and female gonad development. The DGKS pill was significantly associated with eight pathways including the PI3K‐Akt, TNF, NF‐kappa B, and p53 signaling pathways. DGKS pill might have a synergistic effect on the inhibition of excessive sebaceous lipogenesis and sebocyte differentiation, and likewise, anti‐inflammatory effects via the different signaling pathways (PI3K‐Akt, TNF, NF‐kappa B, and p53).