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Successful treatment of resistant onychomycosis with voriconazole in a liver transplant patient
Author(s) -
Nofal Ahmad,
Fawzy Mohamed M.,
ElHawary Esraa E.
Publication year - 2020
Publication title -
dermatologic therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.595
H-Index - 68
eISSN - 1529-8019
pISSN - 1396-0296
DOI - 10.1111/dth.14014
Subject(s) - voriconazole , terbinafine , medicine , dermatophyte , itraconazole , dermatology , trichophyton rubrum , antifungal , nail (fastener) , materials science , metallurgy
Onychomycosis is a common chronic fungal infection of the nails caused by dermatophytes, yeasts, and non‐dermatophyte filamentous fungi. A relatively high incidence of resistance and treatment failure of onychomycosis to traditional systemic antifungal agents such as terbinafine and itraconazole has been reported. Voriconazole is a novel broad spectrum systemic antifungal that has shown high efficacy against various types of dermatophytes including Trichophyton and Microsporum species in many in vitro and, recently, in two in vivo studies of resistant dermatophytosis. Herein, we report the successful treatment of a resistant case of finger nail onychomycosis by oral voriconazole in a liver transplant patient who failed to respond to traditional systemic antifungals.